Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia

Ross P. Carlson, Ashley E. Beck, Poonam Phalak, Matthew W. Fields, Tomas Gedeon, Luke Hanley, William R. Harcombe, Michael A. Henson, Jeffrey J. Heys

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Resource scarcity is a common stress in nature and has a major impact on microbial physiology. This review highlights microbial acclimations to resource scarcity, focusing on resource investment strategies for chemoheterotrophs from the molecular level to the pathway level. Competitive resource allocation strategies often lead to a phenotype known as overflow metabolism; the resulting overflow byproducts can stabilize cooperative interactions in microbial communities and can lead to cross-feeding consortia. These consortia can exhibit emergent properties such as enhanced resource usage and biomass productivity. The literature distilled here draws parallels between in silico and laboratory studies and ties them together with ecological theories to better understand microbial stress responses and mutualistic consortia functioning.

Original languageEnglish (US)
Pages (from-to)269-284
Number of pages16
JournalBiochemical Society transactions
Volume46
Issue number2
DOIs
StatePublished - Apr 17 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).

Fingerprint

Dive into the research topics of 'Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia'. Together they form a unique fingerprint.

Cite this