Competitive adsorption of lung surfactant and serum proteins at the air-liquid interface: A grazing incidence x-ray diffraction study

Patrick C. Stenger, Guohui H. Wu, Eva Y. Chi, Shelli L. Frey, Ka Yee C Lee, Jaroslaw Majewski, Kristian Kjaer, Joseph A. Zasadzinski

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

The competitive adsorption of lung surfactant (LS) and albumin at the air-liquid interface and the ability of polyethylene glycol (PEG) to mediate LS adsorption are analyzed using pressure-area isotherms and grazing incidence x-ray diffraction (GIXD). The addition of albumin drastically reduces the amount of LS on the interface and slightly increases the LS lattice spacing. The addition of PEG restores the characteristic LS peaks, yielding a slightly more compact lattice. The scattering results are consistent with recent work which proposed that albumin creates a physical barrier which eliminates LS adsorption and that PEG enhances LS adsorption but does not significantly change LS surface ordering.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume1027
StatePublished - 2008
Event2007 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 26 2007Nov 30 2007

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