Compensatory smoking from gradual and immediate reduction in cigarette nicotine content

Dorothy K Hatsukami, Eric C. Donny, Joe Koopmeiners, Neal L. Benowitz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Reducing the addictiveness of cigarettes by reducing their nicotine content can potentially have a profound impact on public health. Two different approaches to nicotine reduction have been proposed: gradual and immediate. To determine if either of these approaches results in significant compensatory smoking behavior, which might lead to safety concerns, we performed a secondary analysis of data from studies that have utilized these two approaches. The number of cigarettes smoked per day, carbon monoxide exposure, and cotinine levels in plasma or urine were assessedwhile participants smoked reduced nicotine content cigarettes and compared with when they smoked their usual brand cigarettes. The results showed that in general, these two approaches led to minimal compensatory smoking and reduced levels of cotinine over the course of the experimental period, suggesting that neither of these approaches poses a major safety concern.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2015

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Nicotine
Tobacco Products
Smoking
Cotinine
Safety
Carbon Monoxide
Public Health
Urine

Cite this

Compensatory smoking from gradual and immediate reduction in cigarette nicotine content. / Hatsukami, Dorothy K; Donny, Eric C.; Koopmeiners, Joe; Benowitz, Neal L.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 2, 01.02.2015, p. 472-476.

Research output: Contribution to journalArticle

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