Compensatory adrenal growth is neurally mediated

William C. Engeland, M. F. Dallman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

We have tested the possibility that compensatory adrenal growth is neurally mediated. Small unilateral electrolytic lesions were made in the ventral hypothalamus of young male rats. Subsequently, unilateral adrenalectomy was performed on the side ipsilateral or contralateral to the hypothalamic lesion. Four days later the animals were killed and the remaining adrenal was weighed; the location and extent of the hypothalamic lesions were determined. Lesions placed on the same side as adrenalectomy prevented compensatory growth of the remaining gland (p< 0.005), while lesions on the side opposite to the removed adrenal did not interfere with compensatory adrenal growth. We conclude from these findings, and from a review of some anatomical studies, that compensatory adrenal growth is effected through a reflex that involves both afferent and efferent neural limbs.

Original languageEnglish (US)
Pages (from-to)252-362
Number of pages111
JournalNeuroendocrinology
Volume19
Issue number4
DOIs
StatePublished - 1975

Bibliographical note

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

  • Adrenal nerves
  • Rats
  • Unilateral adrenalectomy
  • Unilateral hypothalamic lesions

Fingerprint Dive into the research topics of 'Compensatory adrenal growth is neurally mediated'. Together they form a unique fingerprint.

Cite this