TY - JOUR
T1 - Compensatory adrenal growth
T2 - a neurally mediated reflex
AU - Dallman, M. F.
AU - Engeland, W. C.
AU - Shinsako, J.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - The responses of young rats to left adrenalectomy or left adrenal manipulation were compared to surgical sham adrenalectomy in which adrenals were observed but not touched. At 12 h right adrenal wet weight, dry weight, DNA, RNA, and protein content were increased (P < 0.05) after the first two operations. Left adrenal manipulation resulted in increased right adrenal weight at 12 h but no change in left adrenal weight. Sequential manipulation of the left adrenal at time O and the right adrenal at 12 h resulted in an enlarged right adrenal at 12 h (P < 0.01), and an enlarged left adrenal at 24 h (P < 0.05), showing that the manipulated gland was capable of response. Bilateral adrenal manipulation of the adrenal glands resulted in bilateral enlargement at 12 h (P < 0.01). Taken together with previous results, these findings strongly suggest that compensatory adrenal growth is a neurally mediated reflex.
AB - The responses of young rats to left adrenalectomy or left adrenal manipulation were compared to surgical sham adrenalectomy in which adrenals were observed but not touched. At 12 h right adrenal wet weight, dry weight, DNA, RNA, and protein content were increased (P < 0.05) after the first two operations. Left adrenal manipulation resulted in increased right adrenal weight at 12 h but no change in left adrenal weight. Sequential manipulation of the left adrenal at time O and the right adrenal at 12 h resulted in an enlarged right adrenal at 12 h (P < 0.01), and an enlarged left adrenal at 24 h (P < 0.05), showing that the manipulated gland was capable of response. Bilateral adrenal manipulation of the adrenal glands resulted in bilateral enlargement at 12 h (P < 0.01). Taken together with previous results, these findings strongly suggest that compensatory adrenal growth is a neurally mediated reflex.
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M3 - Article
C2 - 183516
AN - SCOPUS:0017089164
VL - 231
SP - 408
EP - 414
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 2
ER -