Comparison of quality of life among long-term melanoma survivors and non-melanoma controls: a cross-sectional study

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10 Scopus citations


Purpose: Little is known about specific concerns facing long-term melanoma survivors. The goal of this study was to compare quality of life (QOL) and mental health between long-term melanoma survivors and population controls. Methods: Participants from a previously conducted case-control study of risk factors for melanoma were recruited for a cross-sectional survey. Generic QOL and emotional health were measured using the SF-36 and Hospital Anxiety and Depression Scale questionnaires. A total of 724 melanoma survivors and 660 controls participated. Most melanoma survivors had stage I disease (85.6%); mean time from diagnosis was 9.6 ± 1.0 years. Comparisons of QOL measures between melanoma survivors and controls were conducted using regression models, adjusting for potential confounders. Results: Melanoma survivors, compared to controls, reported statistically significant but only slightly higher physical functioning and bodily pain QOL subscale scores than controls and otherwise similar QOL as measured by the remaining six SF-36 subscale scores. Prevalence of anxiety (18.1% vs. 19.3%, adjusted OR = 1.00 (0.74, 1.36); p = 1.00) and depression (7.2% vs. 9.8%, adjusted OR = 0.74 (0.48, 1.16); p = 1.00) were similar between melanoma survivors and controls. Conclusion: Long-term early stage melanoma survivors report similar general QOL and mental health compared to population controls. Further research is needed to identify concerns more specific to melanoma.

Original languageEnglish (US)
Pages (from-to)1761-1766
Number of pages6
JournalQuality of Life Research
Issue number7
StatePublished - Jul 1 2017

Bibliographical note

Funding Information:
This study was funded by the Masonic Cancer Center of the University of Minnesota and National Institutes of Health National Cancer Institute Grant P30CA077598 and National Center for Advancing Translational Sciences award UL1TR000114. The Masonic Cancer Center Women’s Health Scholar award is sponsored by the University of Minnesota Masonic Cancer Center, a comprehensive cancer center designated by the National Cancer Institute, and administrated by the University of Minnesota Deborah E. Powell Center for Women’s Health.

Publisher Copyright:
© 2017, Springer International Publishing Switzerland.


  • Cancer survivorship
  • Melanoma
  • Quality of life
  • SF-36


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