TY - JOUR
T1 - Comparison of pharmacokinetic parameters of intravenous quinidine and quinine in dogs
AU - Clohisy, Denis R.
AU - Gibson, Thomas P.
PY - 1982
Y1 - 1982
N2 - The pharmacokinetic parameters of quinidine and quinine were determined and compared in seven mongrel dogs. Both drugs were given intravenously, with a minimum of 4 weeks between protocols, and blood samples collected for 20-24 h. Depending on the distribution phase, both two- and three-compartment models were used to describe the kinetics. The volumes of distribution, intercompartmental clearance rates, and volumes of the central and peripheral compartments were similar. The total body clearance (ClT) of quinidine, 3.58 ± 1.96 (SD) ml/kg/min, was 56% slower than that of quinine, 8.11 ± 3.03 ml/kg/min, with p < 0.02. Quinine half-life (t1/2), 6.58 ± 3.3 h, was 54% less than that of quinidine, 14.4 ± 4.10 h, p < 0.02.
AB - The pharmacokinetic parameters of quinidine and quinine were determined and compared in seven mongrel dogs. Both drugs were given intravenously, with a minimum of 4 weeks between protocols, and blood samples collected for 20-24 h. Depending on the distribution phase, both two- and three-compartment models were used to describe the kinetics. The volumes of distribution, intercompartmental clearance rates, and volumes of the central and peripheral compartments were similar. The total body clearance (ClT) of quinidine, 3.58 ± 1.96 (SD) ml/kg/min, was 56% slower than that of quinine, 8.11 ± 3.03 ml/kg/min, with p < 0.02. Quinine half-life (t1/2), 6.58 ± 3.3 h, was 54% less than that of quinidine, 14.4 ± 4.10 h, p < 0.02.
KW - Pharmacokinetics
KW - Quinidine
KW - Quinine
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U2 - 10.1097/00005344-198201000-00017
DO - 10.1097/00005344-198201000-00017
M3 - Article
C2 - 6176784
AN - SCOPUS:0020041501
SN - 0160-2446
VL - 4
SP - 107
EP - 110
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
IS - 1
ER -