Comparison of Patients’ Ethical Perspectives of Preimplantation Embryo Genetic Testing for Aneuploidy (PGT-A) vs. Monogenic Disorders (PGT-M)

J. Zhang, L. R. Rubin, H. Zierhut, L. M. Pastore

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

What are the ethical perspectives of preimplantation genetic testing in patients using/considering PGT-A compared to those using/considering PGT-M? A 17-item questionnaire administered online was used to assess ethical perspectives in US patients who recently used/considered PGT-A (n=80) vs. those who used/considered PGT-M (n=72). Kruskal-Wallis, Chi-square, and Fisher exact tests were conducted with STATA. Most PGT-A and PGT-M users/considerers supported using PGT to screen for diseases fatal in childhood (86–89%) and those causing lifelong disabilities (76–79%) and opposed using PGT to screen for non-medical physical (80–87%) or intellectual traits (74–86%). Both groups agreed that PGT aids in parental decision-making, although some expressed concern over its potential to lead to unforeseen consequences for society and the PGT offspring. More PGT-M than PGT-A users/considerers opposed implanting genetically abnormal embryos when requested by parents (29% PGT-A vs. 56% PGT-M, p = 0.007). For embryo disposition, more PGT-A users/considerers favored freezing (95% PGTA vs. 82% PGT-M, p = 0.018) or donating genetically normal embryos to research (73% PGT-A vs. 57% PGT-M, p = 0.044), while more PGT-M users/considerers supported donating embryos with known genetic abnormalities to research (56% PGT-A vs. 81% PGT-M, p = 0.001). Regardless of the reason for using PGT, users generally agreed on the acceptable and unacceptable uses for it, as well as the potential societal impact. PGT-M users/considerers expressed more opposition than PGT-A users/considerers to implanting embryos with a genetic alteration when requested by the parents.

Original languageEnglish (US)
Pages (from-to)3272-3281
Number of pages10
JournalReproductive Sciences
Volume28
Issue number11
Early online dateJun 15 2021
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
We thank the Reproductive Medicine Associates of New York (especially Alan Copperman, Taraneh Nazem, and Joseph A Lee) and Island Fertility for communicating our study through their clinics. We thank the National Fragile X Foundation and the Parent Project Muscular Dystrophy for communicating our study to their communities. We thank Marci Lobel, PhD, at Stony Brook University for her collaborative work on developing the study questionnaires.

Publisher Copyright:
© 2021, Society for Reproductive Investigation.

Keywords

  • Aneuploidy
  • Attitudes
  • Ethics or ethical issues
  • Monogenic disorders
  • Preimplantation genetic testing

PubMed: MeSH publication types

  • Journal Article

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