Comparison of pallidal and subthalamic stimulation on force control in patient's with Parkinson's disease

Jay L. Alberts, Christopher M. Elder, Michael S. Okun, Jerrold L. Vitek

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The aim of this study was to determine the effects of unilateral deep brain stimulation (DBS) on the control and coordination of grasping forces produced by Parkinson's disease (PD) patients. Ten advanced PD patients with unilateral DBS in the globus pallidus (GPi) or the subthalamic nucleus (STN) (5 patients in each group) performed a functional bimanual dexterous manipulation task. Experiments were performed in the "Off" medication state with DBS "On" and "Off." DBS resulted in (a) significant clinical improvements, (b) greater maximum grip force for both limbs, (c) reduced movement time, and (d) bilateral coupling of grasping forces. There were no significant differences between the GPi and STN groups for any clinical or kinematic measures. DBS of the GPi and STN leads to an improvement in the motor functioning of advanced PD patients. Improvement in force-timing specification during DBS might allow PD patients to employ a feedforward method of force control.

Original languageEnglish (US)
Pages (from-to)484-499
Number of pages16
JournalMotor control
Volume8
Issue number4
DOIs
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • Bimanual coordination
  • Deep brain stimulation
  • Dexterous ability
  • Grip force
  • Load force

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