Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Brent W. Gunderson, Khalid H. Ibrahim, Charles A. Peloquin, Laurie B. Hovde, John C. Rotschafer

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log10 killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.

Original languageEnglish (US)
Pages (from-to)398-399
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2003

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