Comparison of insulin and proinsulin storage in an islet adenoma and adjacent pancreas

Arnold W. Lindall, Michael W Steffes, Edward T. Wong

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The storage of insulin and proinsulin in various subcellular compartments of an islet adenoma and islets from the adjacent pancreas was compared. The tumor had a greater concentration of proinsulin relative to insulin in the secretion granule fraction than the adjacent islets. The microsome fraction from both the adenoma and islets had a larger percentage of proinsulin compared to insulin in contrast to other fractions. In a tolbutamide tolerance test before surgery, the percentage of serum proinsulin relative to insulin was 53% before and 17% after tolbutamide. Proinsulin secretion was temporally separated from insulin secretion in the early phase.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalMetabolism
Volume23
Issue number3
DOIs
StatePublished - Mar 1974

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