Comparison of distortion-product and transient otoacoustic emissions with ABR threshold shift in with ototoxic damage

Akinobu Kakigi, Haruo Hirakawa, Noam Harel, Richard J. Mount, Robert V. Harrison

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

In this study we compare distortion product otoacoustic emissions (DPOAEs), transient evoked otoacoustic emissions (TEOAEs) and ABR threshold shifts in an animal model (chinchilla) of cochlear heating loss. Subjects were treated with an aminoglycoside (amikacin) to produce basal cochlear lesions of various degree. DPOAE and TEOAE were measured throughout the treatment period and until hearing thresholds stabilized. ABR thresholds to tone pip stimuli were determined. Cytocochleograms of cochleas were prepared using scanning microscopy. DPOAEs (2f1-f2) were compared to fast Fourier transform (FFT)-analyzed TEOAEs components in the 1-, 2-, and 4-kHz frequency regions. Both types of emission were compared with corresponding ABR thresholds. There was no significant linear correlation between these different measures of cochlear function. Moreover, the amplitudes of DPOAEs reflected smaller regions of cochlear outer hair cell (OHC) damage better than TEOAEs. These results suggest that DPOAEs can be used to more accurately monitor hair cell function at specific hearing locations than TEOAEs.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalAuris Nasus Larynx
Volume25
Issue number3
DOIs
StatePublished - Sep 1998

Bibliographical note

Funding Information:
This study is supported by MRC (Canada) and The Masonic Foundation of Ontario.

Keywords

  • ABR audiogram
  • Aminoglycoside poisoning
  • Cochleogram
  • DPOAE
  • Hearing loss
  • TEOAE

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