Comparison of cytomegalovirus loads in plasma and leukocytes of patients with cytomegalovirus retinitis

Douglas A. Jabs, Michael Forman, Cheryl Enger, J. Brooks Jackson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Cytomegalovirus (CMV) DNA loads in paired leukocyte and plasma samples from 199 patient visits by 66 patients with CMV retinitis were determined. Leukocyte CMV load determinations had a greater range of values (mean, 24,587 copies/106 leukocytes; maximum, 539,000) than did plasma CMV load determinations (mean, 10,302 copies/ml; maximum, 386,000), and leukocyte vital loads were detectable in a greater proportion of patients at the time of diagnosis of CMV retinitis prior to initiation of anti-CMV therapy (82%) than were plasma viral loads (64%) (P = 0.0078). Agreement with CMV blood cultures was slightly better for plasma (κ = 0.68) than for leukocytes (κ = 0.53), due to a greater proportion of patients with detectable vital loads in leukocytes having negative blood cultures.

Original languageEnglish (US)
Pages (from-to)1431-1435
Number of pages5
JournalJournal of clinical microbiology
Volume37
Issue number5
DOIs
StatePublished - 1999

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