Comparison of asymmetry in cerebral blood flow between brain hemispheres using digital subtraction angiography

Afshin A. Divani, Adnan I. Qureshi, Kenneth R. Hoffman, M. Fareed K. Suri, Jawad F. Kirmani

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background and Purpose. Recently, endovascular techniques have gained significant therapeutic potential for both treatment and prevention of stroke. Cerebral angiography, which is an essential component of these procedures, has been used to provide morphological information regarding condition of blood vessels. In this study, we propose to determine the possibility of acquiring information regarding cerebral blood flow (CBF) in addition to morphologic information from data routinely available during angiography. Methods. Digital subtraction angiography sequences were obtained for eight patients having occlusive disease in internal carotid artery (ICA) territories. Two regions-of-interest (ROIs) corresponding to the two brain hemispheres on AP view were delineated. For each image, the average pixel value within each ROI was calculated and used to generate time-density curves. Indices obtained from each curve were compared with each other and with the results obtained from the single photon emission computed tomography (SPECT) studies performed a pre- or postangiography procedure. Results. Comparison between ICA stenosis and cerebral perfusion measurements revealed that cerebral perfusion deficit can be independent of arterial occlusive disease. The indices obtained from the time-density curves exhibit a correlating trend with the results from SPECT studies. However, lack of sufficient sample data prevented any meaningful statistical analysis to be conducted. Conclusions. We have developed a technique for utilizing the angiographic data for the important task of routinely and easily measuring CBF. Availability of CBF measurements during cerebral angiography may favorably impact upon the appropriate use of endovascular procedures and potentially contribute to the reduction of morbidity and mortality associated with stroke.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalJournal of Neuroimaging
Issue number2
StatePublished - Apr 2006


  • Angiography
  • Cerebral blood flow
  • Ischemic stroke
  • Perfusion
  • Stenosis


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