Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: Location of putative alloantigenic sites

H. T. Orr, J. A. Lopez De Castro, P. Parham, H. L. Ploegh, J. L. Strominger

Research output: Contribution to journalArticle

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Abstract

The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2K(b) heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2K(b) with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.

Original languageEnglish (US)
Pages (from-to)4395-4399
Number of pages5
JournalUnknown Journal
Volume76
Issue number9
DOIs
StatePublished - Jan 1 1979

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HLA-B7 Antigen
Papain
HLA-A2 Antigen
Histocompatibility Antigens
Antigens
Amino acids
Amino Acid Sequence
Membranes
Molecules

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Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7 : Location of putative alloantigenic sites. / Orr, H. T.; Lopez De Castro, J. A.; Parham, P.; Ploegh, H. L.; Strominger, J. L.

In: Unknown Journal, Vol. 76, No. 9, 01.01.1979, p. 4395-4399.

Research output: Contribution to journalArticle

Orr, H. T. ; Lopez De Castro, J. A. ; Parham, P. ; Ploegh, H. L. ; Strominger, J. L. / Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7 : Location of putative alloantigenic sites. In: Unknown Journal. 1979 ; Vol. 76, No. 9. pp. 4395-4399.
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