Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection.

J. E. Lockey, D. N. Williams, L. Raij, L. D. Sabath

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A total of 105 ambulatory patients presenting with symptoms suggestive of cystitis was allocated randomly to a 4 or a 10-day course of doxycycline therapy. Of these patients 62 (59 per cent) had documented infections and 41 (66 per cent) were infected with doxycycline-sensitive organisms: 24 were randomized to a 4-day course and 17 to a 10-day course of antibiotic. The groups were similar with respect to age, history of urinary tract infection, bacteriology and site of infection. Of the 4-day treatment group 90 per cent were free of infection 42 days after completion of therapy, compared to 92 per cent in the 10-day treatment group. Thus, patients with symptoms of cystitis may be treated with a short course of an appropriate antibiotic, provided careful followup is made 4 to 6 weeks after cessation of therapy. The site of urinary infection of doxycycline-resistant and sensitive organisms was determined by the antibody-coated bacteria techniques in 56 episodes: 13 (23 per cent) originated in kidneys, 34 (61 per cent) originated in bladder foci and the results in 9 (16 per cent) were indeterminate. Results of the antibody-coated bacteria technique did not predict therapeutic outcome.
Original languageUndefined/Unknown
Pages (from-to)643-645
Number of pages3
JournalJournal of Urology
Volume124
Issue number5
StatePublished - 1980

Keywords

  • Adolescent
  • Adult
  • Aged
  • Cystitis/dt [Drug Therapy]
  • Cystitis/mi [Microbiology]
  • Cystitis/ur [Urine]
  • Doxycycline/ad [Administration & Dosage]
  • Drug Administration Schedule
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Middle Aged
  • Recurrence
  • Time Factors
  • Urinary Tract Infections/dt [Drug Therapy]
  • Urinary Tract Infections/mi [Microbiology]
  • Urinary Tract Infections/ur [Urine]

Cite this

Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection. / Lockey, J. E.; Williams, D. N.; Raij, L.; Sabath, L. D.

In: Journal of Urology, Vol. 124, No. 5, 1980, p. 643-645.

Research output: Contribution to journalArticle

Lockey, JE, Williams, DN, Raij, L & Sabath, LD 1980, 'Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection.', Journal of Urology, vol. 124, no. 5, pp. 643-645.
Lockey, J. E. ; Williams, D. N. ; Raij, L. ; Sabath, L. D. / Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection. In: Journal of Urology. 1980 ; Vol. 124, No. 5. pp. 643-645.
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T1 - Comparison of 4 and 10 days of doxycycline treatment for urinary tract infection.

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AU - Williams, D. N.

AU - Raij, L.

AU - Sabath, L. D.

PY - 1980

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N2 - A total of 105 ambulatory patients presenting with symptoms suggestive of cystitis was allocated randomly to a 4 or a 10-day course of doxycycline therapy. Of these patients 62 (59 per cent) had documented infections and 41 (66 per cent) were infected with doxycycline-sensitive organisms: 24 were randomized to a 4-day course and 17 to a 10-day course of antibiotic. The groups were similar with respect to age, history of urinary tract infection, bacteriology and site of infection. Of the 4-day treatment group 90 per cent were free of infection 42 days after completion of therapy, compared to 92 per cent in the 10-day treatment group. Thus, patients with symptoms of cystitis may be treated with a short course of an appropriate antibiotic, provided careful followup is made 4 to 6 weeks after cessation of therapy. The site of urinary infection of doxycycline-resistant and sensitive organisms was determined by the antibody-coated bacteria techniques in 56 episodes: 13 (23 per cent) originated in kidneys, 34 (61 per cent) originated in bladder foci and the results in 9 (16 per cent) were indeterminate. Results of the antibody-coated bacteria technique did not predict therapeutic outcome.

AB - A total of 105 ambulatory patients presenting with symptoms suggestive of cystitis was allocated randomly to a 4 or a 10-day course of doxycycline therapy. Of these patients 62 (59 per cent) had documented infections and 41 (66 per cent) were infected with doxycycline-sensitive organisms: 24 were randomized to a 4-day course and 17 to a 10-day course of antibiotic. The groups were similar with respect to age, history of urinary tract infection, bacteriology and site of infection. Of the 4-day treatment group 90 per cent were free of infection 42 days after completion of therapy, compared to 92 per cent in the 10-day treatment group. Thus, patients with symptoms of cystitis may be treated with a short course of an appropriate antibiotic, provided careful followup is made 4 to 6 weeks after cessation of therapy. The site of urinary infection of doxycycline-resistant and sensitive organisms was determined by the antibody-coated bacteria techniques in 56 episodes: 13 (23 per cent) originated in kidneys, 34 (61 per cent) originated in bladder foci and the results in 9 (16 per cent) were indeterminate. Results of the antibody-coated bacteria technique did not predict therapeutic outcome.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cystitis/dt [Drug Therapy]

KW - Cystitis/mi [Microbiology]

KW - Cystitis/ur [Urine]

KW - Doxycycline/ad [Administration & Dosage]

KW - Drug Administration Schedule

KW - Female

KW - Fluorescent Antibody Technique

KW - Humans

KW - Middle Aged

KW - Recurrence

KW - Time Factors

KW - Urinary Tract Infections/dt [Drug Therapy]

KW - Urinary Tract Infections/mi [Microbiology]

KW - Urinary Tract Infections/ur [Urine]

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JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

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ER -