Comparing Blanket vs. Selective Dry Cow Treatment Approaches for Elimination and Prevention of Intramammary Infections During the Dry Period: A Systematic Review and Meta-Analysis

Fidèle Kabera, Jean Philippe Roy, Mohamed Afifi, Sandra Godden, Henrik Stryhn, Javier Sanchez, Simon Dufour

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A systematic review and a series of meta-analyses were conducted to investigate the efficacy of selective dry cow antimicrobial treatment (SDCT) (in which only infected quarters/cows were treated with an antimicrobial) compared with blanket dry cow treatment (BDCT) (all quarters/all cows received an antimicrobial, regardless of their infection status). A full detailed protocol was published before initiating this review. Studies reporting on the (1) proportion of untreated quarters or cows when using SDCT, (2) intramammary infection (IMI) incidence risk over the dry period, (3) IMI elimination risk, (4) post-calving IMI prevalence, (5) early lactation clinical mastitis incidence, or (6) subsequent lactation milk yield and somatic cell counts were considered eligible. Thirteen articles representing 12 controlled trials, whether randomized or not, were available for analyses. SDCT reduced the use of antimicrobials at dry off by 66% (95% CI: 49–80). There was no difference in the elimination of existing IMI at dry off, between SDCT and BDCT. Meta-regression showed that the risk of IMI incidence during the dry period, IMI risk at calving, early lactation clinical mastitis risk, and early lactation milk yield and somatic cell counts did not differ between SDCT and BDCT as long as an internal teat sealant (65% bismuth subnitrate) was administered to untreated healthy quarters/cows at dry off. For trials not using internal teat sealants, SDCT resulted in higher risk than BDCT of acquiring a new IMI during the dry period and of harboring an IMI at calving. Lines of evidence strongly support that SDCT would reduce the use of antimicrobials at dry off, without any detrimental effect on udder health or milk production during the 1st months of the subsequent lactation, if, and only if, internal teat sealants are used for healthy, untreated quarters/cows.

Original languageEnglish (US)
Article number688450
JournalFrontiers in Veterinary Science
Volume8
DOIs
StatePublished - Jun 15 2021

Bibliographical note

Funding Information:
The authors acknowledge Rapha?l Braga, librarian, Facult? de m?decine v?t?rinaire, Universit? de Montr?al, Canada, for his help in developing, elaborating, and validating the search keywords and syntax. Funding. This research was supported by Agriculture and Agri-Food Canada, by additional contributions from Dairy Farmers of Canada, the Canadian Dairy Network, and the Canadian Dairy Commission under the Agri-Science Clusters Initiative, through the Canadian Bovine Mastitis and Milk Quality Research Network research program, and by one of the authors' (SD) NSERC-Discovery grant funds (RGPIN-435637-2013 and RGPIN-2020-05237). FK was also supported by the Fonds de recherche du Qu?bec?Nature et technologies (FRQNT). In addition, FK and MA were supported by the NSERC-CREATE in Milk Quality program.

Funding Information:
This research was supported by Agriculture and Agri-Food Canada, by additional contributions from Dairy Farmers of Canada, the Canadian Dairy Network, and the Canadian Dairy Commission under the Agri-Science Clusters Initiative, through the Canadian Bovine Mastitis and Milk Quality Research Network research program, and by one of the authors’ (SD) NSERC-Discovery grant funds (RGPIN-435637-2013 and RGPIN-2020-05237). FK was also supported by the Fonds de recherche du Québec—Nature et technologies (FRQNT). In

Publisher Copyright:
© Copyright © 2021 Kabera, Roy, Afifi, Godden, Stryhn, Sanchez and Dufour.

Keywords

  • antimicrobial use
  • dairy cows
  • dry period
  • intramammary infection
  • selective antimicrobial treatment

PubMed: MeSH publication types

  • Systematic Review

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