Comparative therapeutic effects of plant-extract synthesized and traditionally synthesized gold nanoparticles on alcohol-induced inflammatory activity in sh-sy5y cells in vitro

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Abstract

The present study describes potential beneficial and adverse effects of plant-extract synthesized gold nanoparticles (AuNPs) on ethanol toxicity in SH-SY5Y cells. Although kudzu root extract (K), edible-gum extract (G), alone or in combination (KG), reduced Au3+ into AuNPs, the extract's composition and the reaction temperature determined their size (AuNPKG(90<50<37) << AuNPK (90,50<37) < AuNP)G (90<50)) the subscript KG, K, or G is extract identification and numerical vales are reaction temperature in Celsius) and biological properties (AuNPKG (90,50>37) << AuNPK (90,50>37) < AuNPG (90,50)) . The surface of each AuNP contained the extract's active ingredients, that were analyzed and confirmed using laser desorption ionization (LDI)) and low-matrix laser desorption-ionization (LMALDI). AuNPKG-50 was (i) least toxic to SH-SY5Y cells, but most effective in suppressing the adverse effects of ethanol on SH-SY5Y cells, and (ii) more effective than a combination of free kudzu and gum extracts. The beneficial and adverse effects of AuNPs may have been modified by the formation of proteins corona. This study provides a proof of concept for possible application of plant-extract synthesized AuNPs in mitigating ethanol toxicity.

Original languageEnglish (US)
Article number70
JournalBiomedicines
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2017

Bibliographical note

Publisher Copyright:
© 2017 by the author.

Keywords

  • Apoptosis
  • Cell viability
  • Edible gum
  • Ethanol
  • Gold nanoparticles
  • Kudzu root
  • Lactate dehydrogenase
  • Lipid peroxidase
  • Necrosis
  • Plant extracts

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