Comparative study on the immunosuppressive and lympholytic activity of optical isomers of cyclophosphamide.

H. Tchórzewski, W. Soszyńska, W. Andrzejewski, K. Pankiewicz, W. J. Stec

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of chirality of cyclophosphamide (Cy) on the reactivity of lymphoid cells in vivo was studied in Balb/c mice. It has been shown that (+) Cy inhibits the formation of direct PFC in Balb/c mice more effectively than (-) Cy. The augmentation of DTH--reaction against HuRBC in mice, measured by the foot-pad test and the elongation of graft survival time were noted when racemic or (-) Cy were applied. Investigated forms of Cy decreased the number of nucleated cells in mice spleens, but lympholytic effect of (+) Cy was lower than that of racemic and (-) Cy. The possible consequences of stereo-differentiated immunosuppressive activity of enantiomeric forms of cyclophosphamide in the experimental procedures and the therapy of "autoimmune" and malignant diseases are considered.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume31
Issue number3
StatePublished - Dec 1 1983

Fingerprint Dive into the research topics of 'Comparative study on the immunosuppressive and lympholytic activity of optical isomers of cyclophosphamide.'. Together they form a unique fingerprint.

Cite this