Comparative study of fourteen alkaloids from Uncaria rhynchophylla hooks and leaves using HPLC-diode array detection-atmospheric pressure chemical ionization/MS method

Jialin Qu, Tianxing Gong, Bin Ma, Lin Zhang, Yoshihiro Kano, Dan Yuan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The purpose of the study is to compare alkaloid profile of Uncaria rhynchophylla hooks and leaves. Ten oxindole alkaloids and four glycosidic indole alkaloids were identified using HPLC-diode array detection (DAD) or LC-atmospheric pressure chemical ionization (APCI)-MS method, and a HPLC-UV method for simultaneous quantification of major alkaloids was validated. The hooks are characterized by high levels of four oxindole alkaloids rhynchophylline (R), isorhynchophylline (IR), corynoxeine (C) and isocorynoxeine (IC), while the leaves contained high level of two glycosidic indole alkaloids vincoside lactam (VL) and strictosidine (S). The presented methods have proven its usefulness in chemical characterization of U. rhynchophylla hooks and leaves.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume60
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Alkaloid profile
  • Glycosidic alkaloid
  • HPLC
  • LC-atmospheric pressure chemical ionization-MS
  • Oxindole alkaloid
  • Uncaria rhynchophylla

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't

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