Comparative pharmacodynamics of three newer fluoroquinolones versus six strains of staphylococci in an in vitro model under aerobic and anaerobic conditions

David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim, John C Rotschafer

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log10 kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs.

Original languageEnglish (US)
Pages (from-to)1561-1563
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume46
Issue number5
DOIs
StatePublished - May 2 2002

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