Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulation and steady-state pharmacokinetic data from hospitalized patients

John C. Rotschafer, Mary Ullman

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

With increasing antibiotic resistance in gram-negative pathogens, dosing strategies that optimize pharmacodynamic parameters of currently available antibiotics play an important role in treatment. The likelihood of success with piperacillin/tazobactam, a widely used broad-spectrum antibiotic, can be manipulated by increasing the amount of time that unbound drug concentrations remain above the pathogen's minimum inhibitory concentration (MIC). However, this success depends greatly on knowing the MIC value as well as accurately estimating the individual's pharmacokinetic parameters. Clinicians should carefully factor these variables into their decision-making process when considering prolonged infusion strategies with piperacillin/tazobactam.

Original languageEnglish (US)
Pages (from-to)1887-1889
Number of pages3
JournalAnnals of Pharmacotherapy
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2009

Keywords

  • Monte Carlo
  • Pharmacodynamics
  • Piperacillin
  • Prolonged infusion
  • Tazobactam

Fingerprint Dive into the research topics of 'Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulation and steady-state pharmacokinetic data from hospitalized patients'. Together they form a unique fingerprint.

  • Cite this