Comparative Pathology of Animal Models for Influenza A Virus Infection

Natalie M. Kirk; Yuying Liang; Hinh Ly

doi:10.3390/pathogens13010035

Comparative Pathology of Animal Models for Influenza A Virus Infection

Natalie M. Kirk, Yuying Liang, Hinh Ly

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Animal models are essential for studying disease pathogenesis and to test the efficacy and safety of new vaccines and therapeutics. For most diseases, there is no single model that can recapitulate all features of the human condition, so it is vital to understand the advantages and disadvantages of each. The purpose of this review is to describe popular comparative animal models, including mice, ferrets, hamsters, and non-human primates (NHPs), that are being used to study clinical and pathological changes caused by influenza A virus infection with the aim to aid in appropriate model selection for disease modeling.

Original language	English (US)
Article number	35
Journal	Pathogens
Volume	13
Issue number	1
DOIs	https://doi.org/10.3390/pathogens13010035
State	Published - Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

IAV
IBV
animal models
influenza virus
pathogenesis
pathology
respiratory pathogens

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathogens13010035

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abstract = "Animal models are essential for studying disease pathogenesis and to test the efficacy and safety of new vaccines and therapeutics. For most diseases, there is no single model that can recapitulate all features of the human condition, so it is vital to understand the advantages and disadvantages of each. The purpose of this review is to describe popular comparative animal models, including mice, ferrets, hamsters, and non-human primates (NHPs), that are being used to study clinical and pathological changes caused by influenza A virus infection with the aim to aid in appropriate model selection for disease modeling.",

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AU - Liang, Yuying

AU - Ly, Hinh

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AB - Animal models are essential for studying disease pathogenesis and to test the efficacy and safety of new vaccines and therapeutics. For most diseases, there is no single model that can recapitulate all features of the human condition, so it is vital to understand the advantages and disadvantages of each. The purpose of this review is to describe popular comparative animal models, including mice, ferrets, hamsters, and non-human primates (NHPs), that are being used to study clinical and pathological changes caused by influenza A virus infection with the aim to aid in appropriate model selection for disease modeling.

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KW - animal models

KW - influenza virus

KW - pathogenesis

KW - pathology

KW - respiratory pathogens

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DO - 10.3390/pathogens13010035

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ER -

Comparative Pathology of Animal Models for Influenza A Virus Infection

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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