Comparative molecular characterization of bovine herpesvirus-1 strains from Egypt and the United States

Nader M. Sobhy, Sunil K. Mor, Mohammed E.M. Mohammed, Iman M. Bastawecy, Hiam M. Fakhry, Christiana R.B. Youssef, Sagar M. Goyal

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bovine herpesvirus 1 (BoHV-1) is an important contagious viral pathogen negatively affecting the livestock industry because of respiratory illness and /or abortion. Most of the disease protection programmes in Egypt depend on imported vaccines and unfortunately molecular studies on molecular and phylogenic analysis of viral strains are rare. Such studies are needed to determine which viral strains should be used in vaccine manufacture so as to provide proper protection to susceptible animals in Egypt. The gB, gC, gD and gE glycoproteins of BoHV-1 are the most important because of their functional properties including virus entry into target cells, viral gene expression, DNA replication, and phylogenetic relationships. This is the first report in which glycoproteins of Egyptian BoHV-1.1 virulent strains have been sequenced and compared with U.S. strains, thus increasing our understanding about the genetic relatedness of various strains of BoHV-1 and between bovine alphaherpesviruses (BoHV-1 and BoHV-5). Our results indicate that the Egyptian Abu-Hammad strains are 100% similar to each other and with U.S. Cooper reference strain suggesting that vaccines based on the latter strain are adequate in providing protection to susceptible animals in Egypt.

Original languageEnglish (US)
Article number82
Pages (from-to)493-499
Number of pages7
JournalLife Science Journal
Volume11
Issue number9
StatePublished - Jan 1 2014

Keywords

  • Bovine herpes virus
  • Egypt
  • Infectious bovine rhinotracheitis
  • Molecular epidemiology
  • Phylogenetic analysis

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