Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human

Ivan Alekseichuk, Kathleen E Mantell, Sina Shirinpour, Alexander Opitz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.

Original languageEnglish (US)
Pages (from-to)136-148
Number of pages13
JournalNeuroImage
Volume194
DOIs
StatePublished - Jul 1 2019

Fingerprint

Transcranial Magnetic Stimulation
Electric Stimulation
Haplorhini
Brain
Head
Cebus
Macaca
Anatomy

Keywords

  • Animal model
  • Finite element modeling
  • Neuromodulation
  • Transcranial electric stimulation
  • Transcranial magnetic stimulation

Cite this

Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human. / Alekseichuk, Ivan; Mantell, Kathleen E; Shirinpour, Sina; Opitz, Alexander.

In: NeuroImage, Vol. 194, 01.07.2019, p. 136-148.

Research output: Contribution to journalArticle

Alekseichuk, Ivan ; Mantell, Kathleen E ; Shirinpour, Sina ; Opitz, Alexander. / Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human. In: NeuroImage. 2019 ; Vol. 194. pp. 136-148.
@article{bc5d78e35c0f4183af3a7b6ebf9d708b,
title = "Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human",
abstract = "Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.",
keywords = "Animal model, Finite element modeling, Neuromodulation, Transcranial electric stimulation, Transcranial magnetic stimulation",
author = "Ivan Alekseichuk and Mantell, {Kathleen E} and Sina Shirinpour and Alexander Opitz",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.neuroimage.2019.03.044",
language = "English (US)",
volume = "194",
pages = "136--148",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Comparative modeling of transcranial magnetic and electric stimulation in mouse, monkey, and human

AU - Alekseichuk, Ivan

AU - Mantell, Kathleen E

AU - Shirinpour, Sina

AU - Opitz, Alexander

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.

AB - Transcranial magnetic stimulation (TMS) and transcranial electric stimulation (TES) are increasingly popular methods to noninvasively affect brain activity. However, their mechanism of action and dose-response characteristics remain under active investigation. Translational studies in animals play a pivotal role in these efforts due to a larger neuroscientific toolset enabled by invasive recordings. In order to translate knowledge gained in animal studies to humans, it is crucial to generate comparable stimulation conditions with respect to the induced electric field in the brain. Here, we conduct a finite element method (FEM) modeling study of TMS and TES electric fields in a mouse, capuchin and macaque monkeys, and a human model. We systematically evaluate the induced electric fields and analyze their relationship to head and brain anatomy. We find that with increasing head size, TMS-induced electric field strength first increases and then decreases according to a two-term exponential function. TES-induced electric field strength strongly decreases from smaller to larger specimen with up to 100x fold differences across species. Our results can serve as a basis to compare and match stimulation parameters across studies in animals and humans.

KW - Animal model

KW - Finite element modeling

KW - Neuromodulation

KW - Transcranial electric stimulation

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=85063375589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063375589&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2019.03.044

DO - 10.1016/j.neuroimage.2019.03.044

M3 - Article

VL - 194

SP - 136

EP - 148

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -