Comparative Inactivation of Three Different Subtypes of Avian Influenza Virus by Ozonized Water

Nader Maher Sobhy, Angie Quiñonez Muñoz, Christiana Rezk Bottros Youssef, Sagar M Goyal

Research output: Contribution to journalArticlepeer-review

Abstract

Avian influenza virus (AIV) causes frequent outbreaks in poultry with high morbidity and mortality. The virus can survive on different fomites, resulting in indirect transmission to susceptible hosts. We investigated the inactivation by ozonated water (O3W) of three different subtypes of AIV (H4N8, H4N6, and H9N9) on seven different fomites. All subtypes were sensitive on all fomites, but there was a slight variation in the sensitivity of different subtypes. For example, AIV H9N9 showed more than 99% reduction on denim fabric, polypropylene, and Styrofoam after 3 min of exposure. More than 97% of H4N8 was eliminated from cardboard, denim fabric, and stainless steel after 3 min of exposure. Subtype H4N6 was the least sensitive; highest inactivation (98%) was seen on cardboard and polypropylene after 3 min of exposure. In conclusion, O3W can inactivate a large percentage of AIV applied to fomites within 3 min in all tested subtypes. Interestingly, an increase in contact time to 10 min did not result in an increase in the virus inactivation rate, probably because of the low half-life of ozone. Further studies are needed to determine how the residual virus can be inactivated so that it does not pose a problem to naïve birds.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalAvian diseases
Volume68
Issue number3
DOIs
StatePublished - Sep 1 2024

Keywords

  • avian influenza virus
  • fomites
  • ozonated water

PubMed: MeSH publication types

  • Journal Article
  • Comparative Study

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