TY - JOUR
T1 - Comparative haemodynamic and metabolic effects of vasodilator and inotropic agents in experimental myocardial infarction
AU - Franciosa, Joseph A.
AU - Notargiacomo, Aldo V.
AU - Cohn, Jay N.
PY - 1978/5
Y1 - 1978/5
N2 - Summary: Following coronary embolisation and onset of left ventricular failure 27 awake dogs were randomly assigned to infusion of saline (controls), nitroprusside, or dobutamine (a new inotropic agent). Nitroprusside and dobutamine both increased cardiac output and lowered left ventricular filling pressure while raising coronary sinus flow. Dobutamine, however, increased myocardial oxygen consumption whereas nitroprusside reduced it. Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction.
AB - Summary: Following coronary embolisation and onset of left ventricular failure 27 awake dogs were randomly assigned to infusion of saline (controls), nitroprusside, or dobutamine (a new inotropic agent). Nitroprusside and dobutamine both increased cardiac output and lowered left ventricular filling pressure while raising coronary sinus flow. Dobutamine, however, increased myocardial oxygen consumption whereas nitroprusside reduced it. Therefore vasodilators may be more beneficial than inotropic agents in acute myocardial infarction.
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U2 - 10.1093/cvr/12.5.294
DO - 10.1093/cvr/12.5.294
M3 - Review article
C2 - 679229
SN - 0008-6363
VL - 12
SP - 294
EP - 302
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 5
ER -