Comparative evaluation of immunization with live attenuated and enhanced-potency inactivated trivalent poliovirus vaccines in childhood: Systemic and local immune responses

Howard Faden, John F. Modlin, Mary Lou Thoms, A. Marshall McBean, Mary Beth Ferdon, Pearay L. Ogra

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

Serum neutralizing, nasopharyngeal neutralizing, and 1gA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and 1gA antibody responses were detected in 41%–88% and 75%–100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production.

Original languageEnglish (US)
Pages (from-to)1291-1297
Number of pages7
JournalJournal of Infectious Diseases
Volume162
Issue number6
DOIs
StatePublished - Dec 1990

Bibliographical note

Funding Information:
Received 27 February 1990; revised 18 June 1990. Informed consent was obtained from parents beforeparticipation. The study was reviewed and approved by the institutional review board. Grant support: Merieux Institute, Miami, and National Institutes of Health (AI-15939). Reprints or correspondence: Dr. Howard Faden, Division of Infectious Diseases, Children's Hospital, 219 Bryant St., Buffalo, NY 14222.

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