Abstract
A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S232-S237 |
| Journal | Journal of Infectious Diseases |
| Volume | 128 |
| DOIs | |
| State | Published - Jan 1 1973 |
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Comparative biological activity of endotoxin and synthetic polyribonucleotides. / Han, Inh H.; Johnson, Arthur G.; Cook, Joseph; Han, Seong S.
In: Journal of Infectious Diseases, Vol. 128, 01.01.1973, p. S232-S237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative biological activity of endotoxin and synthetic polyribonucleotides
AU - Han, Inh H.
AU - Johnson, Arthur G.
AU - Cook, Joseph
AU - Han, Seong S.
PY - 1973/1/1
Y1 - 1973/1/1
N2 - A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.
AB - A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.
UR - http://www.scopus.com/inward/record.url?scp=0015828451&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015828451&partnerID=8YFLogxK
U2 - 10.1093/infdis/128.Supplement_1.S232
DO - 10.1093/infdis/128.Supplement_1.S232
M3 - Article
VL - 128
SP - S232-S237
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
ER -