TY - JOUR
T1 - Comparative biological activity of endotoxin and synthetic polyribonucleotides
AU - Han, Inh H.
AU - Johnson, Arthur G.
AU - Cook, Joseph
AU - Han, Seong S.
PY - 1973/7
Y1 - 1973/7
N2 - A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.
AB - A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.
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U2 - 10.1093/infdis/128.Supplement_1.S232
DO - 10.1093/infdis/128.Supplement_1.S232
M3 - Article
C2 - 4719685
AN - SCOPUS:0015828451
SN - 0022-1899
VL - 128
SP - S232-S237
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -