Comparative biological activity of endotoxin and synthetic polyribonucleotides

Inh H. Han, Arthur G. Johnson, Joseph Cook, Seong S. Han

Research output: Contribution to journalArticle

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Abstract

A comparison of the biological activity of endotoxin with that of synthetic polyribonucleotides was undertaken in search of a nontoxic, practical adjuvant to the immune response. Although both products were effective adjuvants, the action of polynucleotides differed from that of endotoxin in that the former appeared to be mediated through thoracic-duct lymphocytes, causing a decrease in uptake of antigen by this cell, with little effect on formation of germinal centers. In addition, polyadenylic-polyuridylic acid complexes were found to be essentially nontoxic to mice, nonpyrogenic, and incapable of preparing for the local Shwartzman reaction.

Original languageEnglish (US)
Pages (from-to)S232-S237
JournalJournal of Infectious Diseases
Volume128
DOIs
StatePublished - Jan 1 1973

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Polyribonucleotides
Endotoxins
Poly A-U
Shwartzman Phenomenon
Thoracic Duct
Polynucleotides
Germinal Center
Lymphocytes
Antigens

Cite this

Comparative biological activity of endotoxin and synthetic polyribonucleotides. / Han, Inh H.; Johnson, Arthur G.; Cook, Joseph; Han, Seong S.

In: Journal of Infectious Diseases, Vol. 128, 01.01.1973, p. S232-S237.

Research output: Contribution to journalArticle

Han, Inh H. ; Johnson, Arthur G. ; Cook, Joseph ; Han, Seong S. / Comparative biological activity of endotoxin and synthetic polyribonucleotides. In: Journal of Infectious Diseases. 1973 ; Vol. 128. pp. S232-S237.
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