Comparative analysis of several GMR strip sensor configurations for biological applications

Todd Klein; Yi Wang; Liang Tu; Lina Yu; Yinglong Feng; Wei Wang; Jian Ping Wang

doi:10.1016/j.sna.2014.05.033

Comparative analysis of several GMR strip sensor configurations for biological applications

Todd Klein, Yi Wang, Liang Tu, Lina Yu, Yinglong Feng, Wei Wang, Jian Ping Wang

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Giant magnetoresistance (GMR) sensor strips are fabricated and modeled with the purpose of detecting a uniform distribution of Fe₃O₄ magnetic nanoparticles (MNPs) for biological application. We find that the free and fixed layers of GMR sensors play a dominant role in exciting the MNPs, and consequent MNP stray fields lead to increased free layer susceptibility. This result persists even when MNPs are confined to the interior of the sensing region but is enhanced when MNPs are allowed near exterior edges. Our analysis includes three different fabrication configurations on two different spin valve film stacks and agrees well with experimental results.

Original language	English (US)
Pages (from-to)	349-354
Number of pages	6
Journal	Sensors and Actuators, A: Physical
Volume	216
DOIs	https://doi.org/10.1016/j.sna.2014.05.033
State	Published - Sep 1 2014

Bibliographical note

Funding Information:
This work was supported in part by the U.S. Department of Defense W81XWH-11-1-0496 under the Ovarian Cancer Translational Pilot Award. In addition, we acknowledge the support from the Institute for Engineering in Medicine at the University of Minnesota. Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the NINN program.

Funding Information:
We would like to thank Dr. Amy Skubitz, Dr. Kristin Boylan, and Dr. Levi Downs, M.D. for their valuable collaboration on the Ovarian Cancer Translational Pilot Award through the U.S. Department of Defense. Lina Yu and Wei Wang thank the support from Chinese Scholar Council. We would also like to thank the staff at the University of Minnesota Nanofabrication Center and Characterization Facility.

Keywords

Biosensor
GMR
Giant magnetoresistance
Magnetic nanoparticles
Position-dependant sensing

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10.1016/j.sna.2014.05.033

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title = "Comparative analysis of several GMR strip sensor configurations for biological applications",

abstract = "Giant magnetoresistance (GMR) sensor strips are fabricated and modeled with the purpose of detecting a uniform distribution of Fe3O4 magnetic nanoparticles (MNPs) for biological application. We find that the free and fixed layers of GMR sensors play a dominant role in exciting the MNPs, and consequent MNP stray fields lead to increased free layer susceptibility. This result persists even when MNPs are confined to the interior of the sensing region but is enhanced when MNPs are allowed near exterior edges. Our analysis includes three different fabrication configurations on two different spin valve film stacks and agrees well with experimental results.",

keywords = "Biosensor, GMR, Giant magnetoresistance, Magnetic nanoparticles, Position-dependant sensing",

author = "Todd Klein and Yi Wang and Liang Tu and Lina Yu and Yinglong Feng and Wei Wang and Wang, {Jian Ping}",

note = "Funding Information: This work was supported in part by the U.S. Department of Defense W81XWH-11-1-0496 under the Ovarian Cancer Translational Pilot Award. In addition, we acknowledge the support from the Institute for Engineering in Medicine at the University of Minnesota. Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the NINN program. Funding Information: We would like to thank Dr. Amy Skubitz, Dr. Kristin Boylan, and Dr. Levi Downs, M.D. for their valuable collaboration on the Ovarian Cancer Translational Pilot Award through the U.S. Department of Defense. Lina Yu and Wei Wang thank the support from Chinese Scholar Council. We would also like to thank the staff at the University of Minnesota Nanofabrication Center and Characterization Facility. ",

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AU - Klein, Todd

AU - Wang, Yi

AU - Tu, Liang

AU - Yu, Lina

AU - Feng, Yinglong

AU - Wang, Wei

AU - Wang, Jian Ping

N1 - Funding Information: This work was supported in part by the U.S. Department of Defense W81XWH-11-1-0496 under the Ovarian Cancer Translational Pilot Award. In addition, we acknowledge the support from the Institute for Engineering in Medicine at the University of Minnesota. Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the NINN program. Funding Information: We would like to thank Dr. Amy Skubitz, Dr. Kristin Boylan, and Dr. Levi Downs, M.D. for their valuable collaboration on the Ovarian Cancer Translational Pilot Award through the U.S. Department of Defense. Lina Yu and Wei Wang thank the support from Chinese Scholar Council. We would also like to thank the staff at the University of Minnesota Nanofabrication Center and Characterization Facility.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Giant magnetoresistance (GMR) sensor strips are fabricated and modeled with the purpose of detecting a uniform distribution of Fe3O4 magnetic nanoparticles (MNPs) for biological application. We find that the free and fixed layers of GMR sensors play a dominant role in exciting the MNPs, and consequent MNP stray fields lead to increased free layer susceptibility. This result persists even when MNPs are confined to the interior of the sensing region but is enhanced when MNPs are allowed near exterior edges. Our analysis includes three different fabrication configurations on two different spin valve film stacks and agrees well with experimental results.

AB - Giant magnetoresistance (GMR) sensor strips are fabricated and modeled with the purpose of detecting a uniform distribution of Fe3O4 magnetic nanoparticles (MNPs) for biological application. We find that the free and fixed layers of GMR sensors play a dominant role in exciting the MNPs, and consequent MNP stray fields lead to increased free layer susceptibility. This result persists even when MNPs are confined to the interior of the sensing region but is enhanced when MNPs are allowed near exterior edges. Our analysis includes three different fabrication configurations on two different spin valve film stacks and agrees well with experimental results.

KW - Biosensor

KW - GMR

KW - Giant magnetoresistance

KW - Magnetic nanoparticles

KW - Position-dependant sensing

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JO - Sensors and Actuators A: Physical

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SN - 0924-4247

ER -

Comparative analysis of several GMR strip sensor configurations for biological applications

Abstract

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