Comparative actions of monomethoxy amphetamines on the release and uptake of biogenic amines in brain tissue

L. F. Tseng, M. K. Menon, H. H. Loh

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

para Methoxyamphetamine (PMA), a known hallucinogen, is the most potent compound among methoxyamphetamines in disrupting behavior in rats. PMA, unlike d amphetamine (A), did not induce stereotyped behavior and was less effective than A in stimulation of locomotor d amphetamine like effects, but ortho methoxyamphetamine (OMA) was devoid of any locomotor stimulation. To investigate the reasons for the different behavioral effects caused by PMA, meta methoxyamphetamine (MMA), OMA and A, a comparison was made among these drugs on the release and uptake of 3H 5 hydroxytryptamine (3H 5 HT), 3H norepinephrine (3H NE) and 3H dopamine (3H DA) in tissue slices of cerebral cortex and corpus striatum of rat brain. The potencies for the increased release of 3H 5 HT were found to be PMA > MMA ≥ A > OMA in cerebral cortex, of 3H NE in cortex, A ≥ PMA = MMA > OMA, and of 3H DA in corpus striatum, A > MMA > PMA ≥ OMA. The potencies for inhibiting the uptake of 3H 5 HT in cerebral cortex and corpus striatum were found to be PMA > MMA > A > OMA and of 3H NE in cortex A > PMA ≥ MMA > OMA, and 3H DA in corpus striatum A > MMA > PMA > OMA. d PMA is equipotent to l PMA in increasing the release of 3H 5 HT but is more potent than l PMA in blocking the uptake of 3H 5 HT. The high potency of PMA on increasing the release and inhibiting the uptake of 5 HT suggests that 5 HT may be involved in the production of hallucinogenic effects of PMA.

Original languageEnglish (US)
Pages (from-to)263-271
Number of pages9
JournalJournal of Pharmacology and Experimental Therapeutics
Volume197
Issue number2
StatePublished - Jan 1 1976

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