Community-based walking exercise for peripheral artery disease: An exploratory pilot study

Ryan J. Mays, William R. Hiatt, Ivan P. Casserly, R. Kevin Rogers, Deborah S. Main, Wendy M. Kohrt, P. Michael Ho, Judith G. Regensteiner

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Supervised walking exercise is an effective treatment to improve walking ability of patients with peripheral artery disease (PAD), but few exercise programs in community settings have been effective. The aim of this study was to determine the efficacy of a community-based walking exercise program with training, monitoring and coaching (TMC) components to improve exercise performance and patient-reported outcomes in PAD patients. This was a randomized, controlled trial including PAD patients (n=25) who previously received peripheral endovascular therapy or presented with stable claudication. Patients randomized to the intervention group received a comprehensive community-based walking exercise program with elements of TMC over 14 weeks. Patients in the control group did not receive treatment beyond standard advice to walk. The primary outcome in the intent-to-treat (ITT) analyses was peak walking time (PWT) on a graded treadmill. Secondary outcomes included claudication onset time (COT) and patient-reported outcomes assessed via the Walking Impairment Questionnaire (WIQ). Intervention group patients (n=10) did not significantly improve PWT when compared with the control group patients (n=10) (mean±standard error: +2.1±0.7 versus 0.0±0.7 min, p=0.052). Changes in COT and WIQ scores were greater for intervention patients compared with control patients (COT: +1.6±0.8 versus '0.6±0.7 min, p=0.045; WIQ: +18.3±4.2 versus '4.6±4.2%, p=0.001). This pilot using a walking program with TMC and an ITT analysis did not improve the primary outcome in PAD patients. Other walking performance and patient self-reported outcomes were improved following exercise in community settings. Further study is needed to determine whether this intervention improves outcomes in a trial employing a larger sample size.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalVascular Medicine (United Kingdom)
Issue number4
StatePublished - Aug 10 2015


  • activity monitors
  • claudication
  • environmental audit
  • unsupervised exercise

Fingerprint Dive into the research topics of 'Community-based walking exercise for peripheral artery disease: An exploratory pilot study'. Together they form a unique fingerprint.

Cite this