Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study

S. Murakami, K. Otsuka, N. Hotta, G. Yamanaka, Y. Kubo, O. Matsuoka, T. Yamanaka, M. Shinagawa, S. Nunoda, Y. Nishimura, K. Shibata, E. Takasugi, M. Nishinaga, M. Ishine, T. Wada, K. Okumiya, K. Matsubayashi, S. Yano, K. Ichihara, G. CornélissenF. Halberg

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45 Scopus citations

Abstract

Several cohort studies have examined the association of carotid intima-media thickness (IMT) with the risk of stroke or myocardial infarction in apparently healthy persons. We investigated the predictive value of IMT of cardiovascular mortality in elderly community-dwelling people, beyond the prediction provided by age and MMSE, assessed by means of a multivariate Cox model. Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 298 people older than 75 years (120 men and 178 women, average age: 79.6 years). The LILAC study started on July 25, 2000. Consultations were repeated every year. The follow-up ended on November 30, 2004. During the mean follow-up span of 1152 days, 30 subjects (21 men and nine women) died. Nine deaths were attributable to cardiovascular causes (myocardial infarction: two men and three women; stroke: two men and two women). The age- and MMSE-adjusted relative risk (RR) and 95% confidence interval (95% CI) of developing all-cause mortality was assessed. A 0.3 mm increase in left IMT was associated with a RR of predicted 1.647 (1.075-2.524), and a similar increase in right IMT with a RR of 3.327 (1.429-7.746). For cardiovascular mortality, the corresponding RR values were 2.351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people.

Original languageEnglish (US)
Pages (from-to)S49-S53
JournalBiomedicine and Pharmacotherapy
Volume59
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 2005

Keywords

  • All-cause mortality
  • Cardiovascular mortality
  • Carotid intima-media thickness
  • Cognitive function
  • Elderly community-dwelling people

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    Murakami, S., Otsuka, K., Hotta, N., Yamanaka, G., Kubo, Y., Matsuoka, O., Yamanaka, T., Shinagawa, M., Nunoda, S., Nishimura, Y., Shibata, K., Takasugi, E., Nishinaga, M., Ishine, M., Wada, T., Okumiya, K., Matsubayashi, K., Yano, S., Ichihara, K., ... Halberg, F. (2005). Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study. Biomedicine and Pharmacotherapy, 59(SUPPL. 1), S49-S53. https://doi.org/10.1016/S0753-3322(05)80010-1