TY - JOUR
T1 - Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people
T2 - Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study
AU - Murakami, S.
AU - Otsuka, K.
AU - Hotta, N.
AU - Yamanaka, G.
AU - Kubo, Y.
AU - Matsuoka, O.
AU - Yamanaka, T.
AU - Shinagawa, M.
AU - Nunoda, S.
AU - Nishimura, Y.
AU - Shibata, K.
AU - Takasugi, E.
AU - Nishinaga, M.
AU - Ishine, M.
AU - Wada, T.
AU - Okumiya, K.
AU - Matsubayashi, K.
AU - Yano, S.
AU - Ichihara, K.
AU - Cornélissen, G.
AU - Halberg, F.
N1 - Funding Information:
This study was supported by (1) Japan Arteriosclerosis Prevention Fund and (2) Fukuda Foundation for Medical (Grant in 2004 for the study on association between arterial stiffness and cognitive impairment in community-dwelling subjects over 70 years old).
PY - 2005/10
Y1 - 2005/10
N2 - Several cohort studies have examined the association of carotid intima-media thickness (IMT) with the risk of stroke or myocardial infarction in apparently healthy persons. We investigated the predictive value of IMT of cardiovascular mortality in elderly community-dwelling people, beyond the prediction provided by age and MMSE, assessed by means of a multivariate Cox model. Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 298 people older than 75 years (120 men and 178 women, average age: 79.6 years). The LILAC study started on July 25, 2000. Consultations were repeated every year. The follow-up ended on November 30, 2004. During the mean follow-up span of 1152 days, 30 subjects (21 men and nine women) died. Nine deaths were attributable to cardiovascular causes (myocardial infarction: two men and three women; stroke: two men and two women). The age- and MMSE-adjusted relative risk (RR) and 95% confidence interval (95% CI) of developing all-cause mortality was assessed. A 0.3 mm increase in left IMT was associated with a RR of predicted 1.647 (1.075-2.524), and a similar increase in right IMT with a RR of 3.327 (1.429-7.746). For cardiovascular mortality, the corresponding RR values were 2.351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people.
AB - Several cohort studies have examined the association of carotid intima-media thickness (IMT) with the risk of stroke or myocardial infarction in apparently healthy persons. We investigated the predictive value of IMT of cardiovascular mortality in elderly community-dwelling people, beyond the prediction provided by age and MMSE, assessed by means of a multivariate Cox model. Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 298 people older than 75 years (120 men and 178 women, average age: 79.6 years). The LILAC study started on July 25, 2000. Consultations were repeated every year. The follow-up ended on November 30, 2004. During the mean follow-up span of 1152 days, 30 subjects (21 men and nine women) died. Nine deaths were attributable to cardiovascular causes (myocardial infarction: two men and three women; stroke: two men and two women). The age- and MMSE-adjusted relative risk (RR) and 95% confidence interval (95% CI) of developing all-cause mortality was assessed. A 0.3 mm increase in left IMT was associated with a RR of predicted 1.647 (1.075-2.524), and a similar increase in right IMT with a RR of 3.327 (1.429-7.746). For cardiovascular mortality, the corresponding RR values were 2.351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people.
KW - All-cause mortality
KW - Cardiovascular mortality
KW - Carotid intima-media thickness
KW - Cognitive function
KW - Elderly community-dwelling people
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U2 - 10.1016/S0753-3322(05)80010-1
DO - 10.1016/S0753-3322(05)80010-1
M3 - Article
C2 - 16275507
AN - SCOPUS:27744448945
SN - 0753-3322
VL - 59
SP - S49-S53
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - SUPPL. 1
ER -
