Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease

Keyphrases

• Sickle Cell Disease 100%
• Hematologic 100%
• Globin 100%
• Clinical Phenotype 100%
• Coinheritance 60%
• African American 40%
• Chronic Kidney Disease 40%
• Protective Effect 40%
• Anemia 40%
• Thalassemia 40%
• Risk Stratification 20%
• Community-based Cohort 20%
• Jackson Heart Study 20%
• Sickle Cell Anemia 20%
• Mean Corpuscular Volume 20%
• HbA1c Levels 20%
• Functional Assay 20%
• Glycated Hemoglobin A1c 20%
• Cooperative Study 20%
• Red Blood Cell Count 20%
• Red Cell Distribution Width 20%
• Low Estimated Glomerular Filtration Rate 20%
• Mean Corpuscular Hemoglobin 20%
• Risk Counseling 20%
• Regulatory Variants 20%
• Red Blood Cell Parameters 20%
• Red Cell Parameters 20%
• Causal Variant 20%
• Expected Associations 20%
• Thalassemia mutations 20%
• α-globin 20%

Medicine and Dentistry

• Sickle-Cell Disease 100%
• Sickle Cell Trait 100%
• Globin 100%
• Thalassemia 60%
• Inheritance 60%
• Apoplexy 40%
• Chronic Kidney Disease 40%
• Anemia 40%
• Hemoglobin A1c 40%
• Risk Stratification 20%
• Enhancer Region 20%
• Glomerular Filtration Rate 20%
• Glycated Hemoglobin 20%
• Counseling 20%
• Mean Corpuscular Volume 20%
• Erythrocyte Count 20%
• Mean Corpuscular Hemoglobin 20%
• Hemoglobin Alpha Chain 20%
• Erythrocyte 20%

Biochemistry, Genetics and Molecular Biology

• Globin 100%
• Inheritance 60%
• Subcellular Localization 20%
• Glomerulus Filtration 20%
• Enhancer Region 20%
• Mean Corpuscular Volume 20%
• Mean Corpuscular Hemoglobin 20%
• Erythrocyte Count 20%
• Glycated Hemoglobin 20%
• Hemocyte 20%