Commentary on human pluripotent stem cell-based blood–brain barrier models

Ethan S. Lippmann; Samira M. Azarin; Sean P. Palecek; Eric V. Shusta

doi:10.1186/s12987-020-00222-3

Commentary on human pluripotent stem cell-based blood–brain barrier models

Ethan S. Lippmann, Samira M. Azarin, Sean P. Palecek, Eric V. Shusta

Chemical Engineering and Materials Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward.

Original language	English (US)
Article number	64
Journal	Fluids and Barriers of the CNS
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12987-020-00222-3
State	Published - Dec 1 2020

Bibliographical note

Funding Information:
This work was funded in part by grants from the National Institutes of Health (NS103844 and NS107461 to EVS and SPP). Acknowledgements

Keywords

Blood–brain barrier
Human pluripotent stem cell
In vitro model

PubMed: MeSH publication types

Editorial

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10.1186/s12987-020-00222-3

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