Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease

Jinghong Kou, Min Song, Abhinandan Pattanayak, Jeong Eun Lim, Junling Yang, Dongfeng Cao, Ling Li, Ken ichiro Fukuchi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We evaluated the therapeutic efficacy of combined treatment of Aβ-immunization with simvastatin in an Alzheimer mouse model at age 22. months. DNA prime-adenovirus boost immunization induced modest anti-Aβ titers and simvastatin increased the seropositive rate. Aβ-KLH was additionally administered to boost the titers. Irrespective of simvastatin, the immunization did not decrease cerebral Aβ deposits but increased soluble Aβ and tended to exacerbate amyloid angiopathy in the hippocampus. The immunization increased cerebral invasion of leukocytes and simvastatin counteracted the increase. Thus, modest anti-Aβ titers can increase soluble Aβ and simvastatin may reduce inflammation associated with vaccination in aged Alzheimer mouse models.

Original languageEnglish (US)
Pages (from-to)70-83
Number of pages14
JournalJournal of Neuroimmunology
Volume244
Issue number1-2
DOIs
StatePublished - Mar 2012

Keywords

  • Adenovirus
  • Alzheimer's disease
  • Amyloid
  • Inflammation
  • Statin
  • Vaccine

Fingerprint Dive into the research topics of 'Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this