Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability

Sebastian Weingärtner, Mehmet Akçakaya, Tamer Basha, Kraig V. Kissinger, Beth Goddu, Sophie Berg, Warren J. Manning, Reza Nezafat

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Purpose To develop arrhythmia-insensitive inversion recovery sequences for improved visualization of myocardial scar and quantification of diffuse fibrosis. Methods A novel preparation pre-pulse, called saturation pulse prepared heart-rate-independent inversion recovery, is introduced, which consists of a combination of saturation and inversion pulses to remove the magnetization history in each heartbeat in late gadolinium enhancement (LGE) imaging and eliminate the need for rest periods in T1 mapping. The proposed LGE and T1 mapping sequences were evaluated against conventional LGE and modified Look-Locker inversion sequences using numerical simulations, phantom and imaging in healthy subjects and patients with suspected or known cardiovascular disease. Results Simulations and phantom experiments show that the saturation pulse prepared heart-rate-independent inversion recovery pre-pulse in LGE reduces ghosting artifacts and results in perfect nulling of the healthy myocardium in the presence of arrhythmia. In T 1 mapping, saturation pulse prepared heart-rate-independent inversion recovery results in (a) reduced scan time (17 vs. 9 heartbeats), (b) insensitivity to heart rate for long T1, and (c) increased signal homogeneity for short T1. LGE images in a patient in atrial fibrillation during the scan show improved myocardial nulling. In vivo T 1 maps demonstrate increased signal homogeneity in blood pools and myocardium. Conclusion The proposed sequences are insensitive to heart rate variability, yield improved LGE images in the presence of arrhythmias, as well as T1 mapping with shorter scan times.

Original languageEnglish (US)
Pages (from-to)1024-1034
Number of pages11
JournalMagnetic resonance in medicine
Volume71
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • atrial fibrillation
  • diffuse fibrosis
  • heart rate variability
  • late gadolinium enhancement
  • scar imaging

Fingerprint Dive into the research topics of 'Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability'. Together they form a unique fingerprint.

  • Cite this