COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE

Scott T Hansen; John Higgins; David Wood

COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE

Scott T Hansen, John Higgins, David Wood

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Combined studies in blood rheological behavior and hemoglobin oxygen saturation can help in understanding investigational drugs for sickle cell disease (SCD) from both a therapeutic and mechanistic perspective. We have modified a microfluidic platform to evaluate rheological behavior and changes in hemoglobin (Hb) oxygen affinity after treatment with oxygen affinity-shifting compounds. The results show both a reduction in the oxygen-dependent rheology of SCD blood and increased Hb oxygen affinity. This platform improves upon previous devices that solely analyze the fluid behavior of blood in that it can identify beneficial shifts in Hb oxygen affinity without the need for additional testing.

Original language	English (US)
Title of host publication	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	667-668
Number of pages	2
ISBN (Electronic)	9781733419031
State	Published - 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States Duration: Oct 10 2021 → Oct 14 2021

Publication series

Name	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/Territory	United States
City	Palm Springs, Virtual
Period	10/10/21 → 10/14/21

Bibliographical note

Funding Information:
The authors were supported by NHLBI grant R01HL132906 to DKW. Portions of this work were conducted in the Minnesota Nano Center, which was supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award No. ECCS-1542202.

Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

Keywords

blood flow
oxygen saturation
rheology
Sickle cell disease
spectroscopy
Voxelotor

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Hansen, S. T., Higgins, J., & Wood, D. (2021). COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 667-668). (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE. / Hansen, Scott T; Higgins, John; Wood, David.
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2021. p. 667-668 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hansen, ST, Higgins, J & Wood, D 2021, COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 667-668, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.

Hansen ST, Higgins J, Wood D. COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2021. p. 667-668. (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Hansen, Scott T ; Higgins, John ; Wood, David. / COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2021. pp. 667-668 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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abstract = "Combined studies in blood rheological behavior and hemoglobin oxygen saturation can help in understanding investigational drugs for sickle cell disease (SCD) from both a therapeutic and mechanistic perspective. We have modified a microfluidic platform to evaluate rheological behavior and changes in hemoglobin (Hb) oxygen affinity after treatment with oxygen affinity-shifting compounds. The results show both a reduction in the oxygen-dependent rheology of SCD blood and increased Hb oxygen affinity. This platform improves upon previous devices that solely analyze the fluid behavior of blood in that it can identify beneficial shifts in Hb oxygen affinity without the need for additional testing.",

keywords = "blood flow, oxygen saturation, rheology, Sickle cell disease, spectroscopy, Voxelotor",

author = "Hansen, {Scott T} and John Higgins and David Wood",

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N1 - Funding Information: The authors were supported by NHLBI grant R01HL132906 to DKW. Portions of this work were conducted in the Minnesota Nano Center, which was supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award No. ECCS-1542202. Publisher Copyright: © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

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AB - Combined studies in blood rheological behavior and hemoglobin oxygen saturation can help in understanding investigational drugs for sickle cell disease (SCD) from both a therapeutic and mechanistic perspective. We have modified a microfluidic platform to evaluate rheological behavior and changes in hemoglobin (Hb) oxygen affinity after treatment with oxygen affinity-shifting compounds. The results show both a reduction in the oxygen-dependent rheology of SCD blood and increased Hb oxygen affinity. This platform improves upon previous devices that solely analyze the fluid behavior of blood in that it can identify beneficial shifts in Hb oxygen affinity without the need for additional testing.

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COMBINED ON-CHIP SPECTROSCOPY AND RHEOLOGY AS A PRECLINICAL DRUG SCREENING TOOL FOR SICKLE CELL DISEASE

Abstract

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Bibliographical note

Keywords

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