Abstract
The combined effect of mussel-inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA-modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1445-1450 |
| Number of pages | 6 |
| Journal | Advanced Healthcare Materials |
| Volume | 2 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2013 |
| Externally published | Yes |
Keywords
- Mussel adhesion
- Myogenic differentiation
- Nanofiber alignment
- Polydopamine
- Skeletal tissue engineering