Combined action of penicillin g with methicillin or oxacillzn against staphylococcus aureus.

L. D. Sabath, B. W. Steinhauer, M. Finland

Research output: Contribution to journalArticle

Abstract

When serial dilutions of penicillin G, which is destroyed by staphylococcal penicillinase, were nixed with various dilutions of each of 2 semisynthetic penicillinaseresistant penicillins (such as methicillin and oxacillin). the combined action against 5 strains of staphylococci (of which 4 were resistant to penicillin G) was always at least as good as that of the more active of the mixture. Synergism was not observed, but in some assays the action was significantly less than additive against resistant penicillinase-producing strains. Penicillin in combination with one of the new eemisynthetic. penicillinase-resistant penicillins could therefore be used to initiate therapy of serious staphylococcal infections, until the results of sensitivity tests become available, after which the appropriate type of penicillin should be used.
Original languageUndefined/Unknown
Pages (from-to)596-605
Number of pages10
JournalNew England Journal of Medicine
Volume268
Issue number6
StatePublished - 1963

Keywords

  • assay
  • dilution
  • measles
  • Staphylococcus
  • Staphylococcus aureus
  • Staphylococcus infection
  • therapy
  • vaccination
  • meticillin
  • oxacillin
  • penicillin derivative
  • penicillin G
  • penicillinase

Cite this

Combined action of penicillin g with methicillin or oxacillzn against staphylococcus aureus. / Sabath, L. D.; Steinhauer, B. W.; Finland, M.

In: New England Journal of Medicine, Vol. 268, No. 6, 1963, p. 596-605.

Research output: Contribution to journalArticle

Sabath, L. D. ; Steinhauer, B. W. ; Finland, M. / Combined action of penicillin g with methicillin or oxacillzn against staphylococcus aureus. In: New England Journal of Medicine. 1963 ; Vol. 268, No. 6. pp. 596-605.
@article{bdeca3cdcb3744cfad312ceef15a1a85,
title = "Combined action of penicillin g with methicillin or oxacillzn against staphylococcus aureus.",
abstract = "When serial dilutions of penicillin G, which is destroyed by staphylococcal penicillinase, were nixed with various dilutions of each of 2 semisynthetic penicillinaseresistant penicillins (such as methicillin and oxacillin). the combined action against 5 strains of staphylococci (of which 4 were resistant to penicillin G) was always at least as good as that of the more active of the mixture. Synergism was not observed, but in some assays the action was significantly less than additive against resistant penicillinase-producing strains. Penicillin in combination with one of the new eemisynthetic. penicillinase-resistant penicillins could therefore be used to initiate therapy of serious staphylococcal infections, until the results of sensitivity tests become available, after which the appropriate type of penicillin should be used.",
keywords = "assay, dilution, measles, Staphylococcus, Staphylococcus aureus, Staphylococcus infection, therapy, vaccination, meticillin, oxacillin, penicillin derivative, penicillin G, penicillinase",
author = "Sabath, {L. D.} and Steinhauer, {B. W.} and M. Finland",
year = "1963",
language = "Undefined/Unknown",
volume = "268",
pages = "596--605",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "6",

}

TY - JOUR

T1 - Combined action of penicillin g with methicillin or oxacillzn against staphylococcus aureus.

AU - Sabath, L. D.

AU - Steinhauer, B. W.

AU - Finland, M.

PY - 1963

Y1 - 1963

N2 - When serial dilutions of penicillin G, which is destroyed by staphylococcal penicillinase, were nixed with various dilutions of each of 2 semisynthetic penicillinaseresistant penicillins (such as methicillin and oxacillin). the combined action against 5 strains of staphylococci (of which 4 were resistant to penicillin G) was always at least as good as that of the more active of the mixture. Synergism was not observed, but in some assays the action was significantly less than additive against resistant penicillinase-producing strains. Penicillin in combination with one of the new eemisynthetic. penicillinase-resistant penicillins could therefore be used to initiate therapy of serious staphylococcal infections, until the results of sensitivity tests become available, after which the appropriate type of penicillin should be used.

AB - When serial dilutions of penicillin G, which is destroyed by staphylococcal penicillinase, were nixed with various dilutions of each of 2 semisynthetic penicillinaseresistant penicillins (such as methicillin and oxacillin). the combined action against 5 strains of staphylococci (of which 4 were resistant to penicillin G) was always at least as good as that of the more active of the mixture. Synergism was not observed, but in some assays the action was significantly less than additive against resistant penicillinase-producing strains. Penicillin in combination with one of the new eemisynthetic. penicillinase-resistant penicillins could therefore be used to initiate therapy of serious staphylococcal infections, until the results of sensitivity tests become available, after which the appropriate type of penicillin should be used.

KW - assay

KW - dilution

KW - measles

KW - Staphylococcus

KW - Staphylococcus aureus

KW - Staphylococcus infection

KW - therapy

KW - vaccination

KW - meticillin

KW - oxacillin

KW - penicillin derivative

KW - penicillin G

KW - penicillinase

M3 - Article

VL - 268

SP - 596

EP - 605

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 6

ER -