Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma

Adam L. Burrack, Ellen J. Spartz, Jackson F. Raynor, Iris Wang, Margaret Olson, Ingunn M Stromnes

Research output: Contribution to journalArticle

Abstract

Burrack et al. investigate tumor-specific T cells during immunotherapy of pancreas cancer. T cells accumulate intratumorally yet rapidly exhaust. Combined PD-1 + PD-L1 blockade promotes peripheral T cell expansion, TNFα production, and eradication of spontaneous tumor recurrence in 50% of animals. Tumor variants defective in IFNγ-inducible Tap1 and MHC class I ultimately emerge.

Original languageEnglish (US)
Pages (from-to)2140-2155.e6
JournalCell reports
Volume28
Issue number8
DOIs
StatePublished - Aug 20 2019

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T-cells
Cellular Immunity
Tumors
Adenocarcinoma
T-Lymphocytes
Neoplasms
Pancreatic Neoplasms
Immunotherapy
Animals
Recurrence

Keywords

  • PD-1
  • PD-L1
  • PDA
  • T cells
  • acquired resistance
  • immunotherapy
  • neoepitope
  • pancreatic cancer

PubMed: MeSH publication types

  • Journal Article

Cite this

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. / Burrack, Adam L.; Spartz, Ellen J.; Raynor, Jackson F.; Wang, Iris; Olson, Margaret; Stromnes, Ingunn M.

In: Cell reports, Vol. 28, No. 8, 20.08.2019, p. 2140-2155.e6.

Research output: Contribution to journalArticle

Burrack, Adam L. ; Spartz, Ellen J. ; Raynor, Jackson F. ; Wang, Iris ; Olson, Margaret ; Stromnes, Ingunn M. / Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma. In: Cell reports. 2019 ; Vol. 28, No. 8. pp. 2140-2155.e6.
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