Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model

Jie Zhang, Jian Sun, Xiyue Chen, Cunxi Nie, Jinbiao Zhao, Wenyi Guan, Lihui Lei, Ting He, Yiqiang Chen, Lee J. Johnston, Jinshan Zhao, Xi Ma

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here Clostridium butyricum (C. butyricum, C.B) combined with corn bran (C.B + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal health over 28 days postweaning. Growth performance, fecal short chain fatty acids (SCFAs) and bacterial community were evaluated at day 14 and day 28 of the trial. Although the C.B + Bran treatment has no significant effects on growth performance (P > 0.05), it optimized the composition of intestinal bacteria, mainly represented by increased acetate-producing bacteria and decreased pathogens. Microbial fermentation in the intestine showed a shift from low acetate and isovalerate production on day 14 to enhanced acetate production on day 28 in the C.B + Bran treatment. Thus, C.B and corn bran promoted intestinal microbial fermentation and optimized the microbial community for pigs at an early age. These findings provide perspectives on the advantages of synbiotics as a new approach for effective utilization of corn barn.

Original languageEnglish (US)
Article number3091
JournalFrontiers in Microbiology
Volume9
DOIs
StatePublished - Mar 29 2018

Bibliographical note

Funding Information:
This work was supported by the National Key R&D Program of China (2018YFD0500601 and 2017YFD0500501), the National Natural Science Foundation of China (31829004, 31722054, and 31472101), the College of Animal Science and Technology “Young Talents Program” at China Agricultural University (2017DKA001), the Beijing Nova Programme Interdisciplinary Cooperation Project (xxjc201804), the 111 Project (B16044), the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd., and the Apply Basic Research Project in Xinjiang Production and Construction Crops of

Publisher Copyright:
© Copyright © 2018 Zhang, Sun, Chen, Nie, Zhao, Guan, Lei, He, Chen, Johnston, Zhao and Ma.

Keywords

  • Clostridium butyricum
  • corn bran
  • intestinal bacteria
  • short chain fatty acids
  • synbiotics
  • weaned pig model

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