Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.
Bibliographical noteFunding Information:
This project was supported by funds from the National Science Foundation (NSF) Career Award DMR-1151529, the University of Minnesota Institute for Engineering in Medicine, the University of Minnesota Academic Health Center, and the University of Minnesota Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME). A. S. was supported by a Biotechnology Training Grant (NIH T32GM008347) and the Institute for Molecular Virology Training Program (NIH T32 AI83196). Parts of this work were carried out in the Characterization Facility at the University of Minnesota, which receives partial support from NSF through the MRSEC program.
© The Royal Society of Chemistry.