Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Allison Siehr; Bin Xu; Ronald A. Siegel; Wei Shen

doi:10.1039/c9sm01314h

Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Allison Siehr, Bin Xu, Ronald A. Siegel, Wei Shen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.

Original language	English (US)
Pages (from-to)	7122-7126
Number of pages	5
Journal	Soft Matter
Volume	15
Issue number	36
DOIs	https://doi.org/10.1039/c9sm01314h
State	Published - 2019

Bibliographical note

Funding Information:
This project was supported by funds from the National Science Foundation (NSF) Career Award DMR-1151529, the University of Minnesota Institute for Engineering in Medicine, the University of Minnesota Academic Health Center, and the University of Minnesota Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME). A. S. was supported by a Biotechnology Training Grant (NIH T32GM008347) and the Institute for Molecular Virology Training Program (NIH T32 AI83196). Parts of this work were carried out in the Characterization Facility at the University of Minnesota, which receives partial support from NSF through the MRSEC program.

Publisher Copyright:
© The Royal Society of Chemistry.

Publisher link

10.1039/c9sm01314h

Find It

Find It at U of M Libraries

Cite this

@article{5e4c29229e7040c08ca352cb95912193,

title = "Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions",

abstract = "Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.",

author = "Allison Siehr and Bin Xu and Siegel, {Ronald A.} and Wei Shen",

note = "Funding Information: This project was supported by funds from the National Science Foundation (NSF) Career Award DMR-1151529, the University of Minnesota Institute for Engineering in Medicine, the University of Minnesota Academic Health Center, and the University of Minnesota Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME). A. S. was supported by a Biotechnology Training Grant (NIH T32GM008347) and the Institute for Molecular Virology Training Program (NIH T32 AI83196). Parts of this work were carried out in the Characterization Facility at the University of Minnesota, which receives partial support from NSF through the MRSEC program. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9sm01314h",

language = "English (US)",

volume = "15",

pages = "7122--7126",

journal = "Soft Matter",

issn = "1744-683X",

publisher = "Royal Society of Chemistry",

number = "36",

}

TY - JOUR

T1 - Colloidal stability

T2 - Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

AU - Siehr, Allison

AU - Xu, Bin

AU - Siegel, Ronald A.

AU - Shen, Wei

N1 - Funding Information: This project was supported by funds from the National Science Foundation (NSF) Career Award DMR-1151529, the University of Minnesota Institute for Engineering in Medicine, the University of Minnesota Academic Health Center, and the University of Minnesota Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME). A. S. was supported by a Biotechnology Training Grant (NIH T32GM008347) and the Institute for Molecular Virology Training Program (NIH T32 AI83196). Parts of this work were carried out in the Characterization Facility at the University of Minnesota, which receives partial support from NSF through the MRSEC program. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.

AB - Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=85072357732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072357732&partnerID=8YFLogxK

U2 - 10.1039/c9sm01314h

DO - 10.1039/c9sm01314h

M3 - Article

C2 - 31498366

AN - SCOPUS:85072357732

VL - 15

SP - 7122

EP - 7126

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 36

ER -

Colloidal stability: Versus self-assembly of nanoparticles controlled by coiled-coil protein interactions

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this