Collision-Induced Dissociation Mass Spectrometry: A Powerful Tool for Natural Product Structure Elucidation

Andrew R. Johnson, Erin E. Carlson

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.

Original languageEnglish (US)
Pages (from-to)10668-10678
Number of pages11
JournalAnalytical chemistry
Volume87
Issue number21
DOIs
StatePublished - Nov 3 2015

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