TY - JOUR
T1 - Collision-Induced Dissociation Mass Spectrometry
T2 - A Powerful Tool for Natural Product Structure Elucidation
AU - Johnson, Andrew R.
AU - Carlson, Erin E.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/11/3
Y1 - 2015/11/3
N2 - Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.
AB - Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.
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U2 - 10.1021/acs.analchem.5b01543
DO - 10.1021/acs.analchem.5b01543
M3 - Review article
C2 - 26132379
AN - SCOPUS:84946594373
SN - 0003-2700
VL - 87
SP - 10668
EP - 10678
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 21
ER -