Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior

Steven R. Caliari; Emily A. Gonnerman; William K. Grier; Daniel W. Weisgerber; Jessica M. Banks; Aurora J. Alsop; Jae Sung Lee; Ryan C. Bailey; Brendan A.C. Harley

doi:10.1002/adhm.201400252

Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior

Steven R. Caliari, Emily A. Gonnerman, William K. Grier, Daniel W. Weisgerber, Jessica M. Banks, Aurora J. Alsop, Jae Sung Lee, Ryan C. Bailey, Brendan A.C. Harley

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.

Original language	English (US)
Pages (from-to)	58-64
Number of pages	7
Journal	Advanced Healthcare Materials
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/adhm.201400252
State	Published - Jan 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Arrays
Collagen
Freeze-drying
Gradients
Mesenchymal stem cells

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10.1002/adhm.201400252

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title = "Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior",

abstract = "Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.",

keywords = "Arrays, Collagen, Freeze-drying, Gradients, Mesenchymal stem cells",

author = "Caliari, {Steven R.} and Gonnerman, {Emily A.} and Grier, {William K.} and Weisgerber, {Daniel W.} and Banks, {Jessica M.} and Alsop, {Aurora J.} and Lee, {Jae Sung} and Bailey, {Ryan C.} and Harley, {Brendan A.C.}",

note = "Publisher Copyright: {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = jan,

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doi = "10.1002/adhm.201400252",

language = "English (US)",

volume = "4",

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T1 - Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior

AU - Caliari, Steven R.

AU - Gonnerman, Emily A.

AU - Grier, William K.

AU - Weisgerber, Daniel W.

AU - Banks, Jessica M.

AU - Alsop, Aurora J.

AU - Lee, Jae Sung

AU - Bailey, Ryan C.

AU - Harley, Brendan A.C.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.

AB - Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.

KW - Arrays

KW - Collagen

KW - Freeze-drying

KW - Gradients

KW - Mesenchymal stem cells

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EP - 64

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 1

ER -

Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior

Abstract

Bibliographical note

Keywords

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