TY - JOUR
T1 - Collagen biomarkers predict new onset of hypertension in normotensive participants
T2 - The Multi-Ethnic Study of Atherosclerosis
AU - Duprez, Daniel A.
AU - Gross, Myron D.
AU - Ix, Joachim H.
AU - Kizer, Jorge R.
AU - Tracy, Russell P.
AU - Shea, Steven
AU - Jacobs, David R.
N1 - Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Objective: Vascular remodeling associated with increased extracellular matrix (ECM) may precede hypertension. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen turnover and are important in ECM remodeling. PIIINP and ICTP are increased in cardiovascular diseases (CVD). We hypothesized that PIIINP and ICTP among normotensives predict incident hypertension. Methods: We included 1252 Multi-Ethnic Study of Atherosclerosis participants with mean age 58.1-12.4 years, 48% men, free of overt CVD, having SBP and DBP less than 130/85mmHg and not using any antihypertensive medication, and having plasma PIIINP and ICTP measurements, all assessed at baseline. We studied the association of baseline PIIINP and ICTP with the relative incidence density (RID) of incident hypertension, defined as SBP/DBP at least 140/90 mmHg, or antihypertensive therapy use during follow-up (four examinations over median 9.4 years). Results: Baseline mean SBP/DBP was 110.9-14.0/ 67.9-10.4 mmHg. Mean concentration of PIIINP was 5.39-1.95mg/l and ICTP was 3.18-1.39mg/l. During follow-up visits, 35.9% of the participants developed hypertension. After adjustment for age, race, and sex there was a significant RID for new onset of hypertension of 1.16 (1.06, 1.28), P=0.0017 for PIIINP and 1.20 (1.08,1.33) for ICTP, P=0.0008. After additional adjustment for renal function, CVD risk factors and inflammatory variables, RID for new onset hypertension was 1.28 (1.15,1.42), P<0.001 for PIIINP and 1.29 (1.15,1.44) for ICTP, P<0.0001. Conclusion: Biomarkers of ECM remodeling predicted the development of hypertension in normotensive participants free of overt CVD.
AB - Objective: Vascular remodeling associated with increased extracellular matrix (ECM) may precede hypertension. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen turnover and are important in ECM remodeling. PIIINP and ICTP are increased in cardiovascular diseases (CVD). We hypothesized that PIIINP and ICTP among normotensives predict incident hypertension. Methods: We included 1252 Multi-Ethnic Study of Atherosclerosis participants with mean age 58.1-12.4 years, 48% men, free of overt CVD, having SBP and DBP less than 130/85mmHg and not using any antihypertensive medication, and having plasma PIIINP and ICTP measurements, all assessed at baseline. We studied the association of baseline PIIINP and ICTP with the relative incidence density (RID) of incident hypertension, defined as SBP/DBP at least 140/90 mmHg, or antihypertensive therapy use during follow-up (four examinations over median 9.4 years). Results: Baseline mean SBP/DBP was 110.9-14.0/ 67.9-10.4 mmHg. Mean concentration of PIIINP was 5.39-1.95mg/l and ICTP was 3.18-1.39mg/l. During follow-up visits, 35.9% of the participants developed hypertension. After adjustment for age, race, and sex there was a significant RID for new onset of hypertension of 1.16 (1.06, 1.28), P=0.0017 for PIIINP and 1.20 (1.08,1.33) for ICTP, P=0.0008. After additional adjustment for renal function, CVD risk factors and inflammatory variables, RID for new onset hypertension was 1.28 (1.15,1.42), P<0.001 for PIIINP and 1.29 (1.15,1.44) for ICTP, P<0.0001. Conclusion: Biomarkers of ECM remodeling predicted the development of hypertension in normotensive participants free of overt CVD.
KW - Blood pressure
KW - Cohort study
KW - Collagen type I carboxy-terminal telopeptide
KW - Hypertension
KW - Incidence
KW - Procollagen type III N-terminal propeptide
UR - http://www.scopus.com/inward/record.url?scp=85064118045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064118045&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000001793
DO - 10.1097/HJH.0000000000001793
M3 - Article
C2 - 29782392
AN - SCOPUS:85064118045
SN - 0263-6352
VL - 36
SP - 2245
EP - 2250
JO - Journal of hypertension
JF - Journal of hypertension
IS - 11
ER -