Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Lisa A. Kroeger; Laurie B. Hovde; Isaac F. Mitropoulos; Jeremy Schafer; John C Rotschafer

doi:10.1128/AAC.01433-06

Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Lisa A. Kroeger
, Laurie B. Hovde
, Isaac F. Mitropoulos
, Jeremy Schafer
, John C Rotschafer

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

Original language	English (US)
Pages (from-to)	3431-3433
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01433-06
State	Published - Sep 2007

Publisher link

10.1128/AAC.01433-06

Find It

Find It at U of M Libraries

Cite this

@article{717ca473b85145fc95d97f6314a66e72,

title = "Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model",

abstract = "Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.",

author = "Kroeger, \{Lisa A.\} and Hovde, \{Laurie B.\} and Mitropoulos, \{Isaac F.\} and Jeremy Schafer and Rotschafer, \{John C\}",

year = "2007",

month = sep,

doi = "10.1128/AAC.01433-06",

language = "English (US)",

volume = "51",

pages = "3431--3433",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

AU - Kroeger, Lisa A.

AU - Hovde, Laurie B.

AU - Mitropoulos, Isaac F.

AU - Schafer, Jeremy

AU - Rotschafer, John C

PY - 2007/9

Y1 - 2007/9

N2 - Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

AB - Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

UR - https://www.scopus.com/pages/publications/35348937025

UR - https://www.scopus.com/pages/publications/35348937025#tab=citedBy

U2 - 10.1128/AAC.01433-06

DO - 10.1128/AAC.01433-06

M3 - Article

C2 - 17576842

AN - SCOPUS:35348937025

SN - 0066-4804

VL - 51

SP - 3431

EP - 3433

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 9

ER -

Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this