Colistin methanesulfonate against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacodynamic model

Lisa A. Kroeger, Laurie B. Hovde, Isaac F. Mitropoulos, Jeremy Schafer, John C Rotschafer

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Using an in vitro pharmacodynamic model, a multidrug-resistant strain of Acinetobacter baumannii was exposed to colistin methanesulfonate alone and in combination with ceftazidime. Pre- and postexposure colistin sulfate MICs were determined. A single daily dose of colistin methanesulfonate combined with continuous-infusion ceftazidime prevented regrowth and postexposure MIC increases.

Original languageEnglish (US)
Pages (from-to)3431-3433
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number9
DOIs
StatePublished - Sep 1 2007

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