Coinheritance of α-thalassemia-1 and hemoglobin E/β0-thalassemia: Practical implications for neonatal screening and genetic counseling

L. Krishnamurti, D. H.K. Chui, M. Dallaire, B. LeRoy, J. S. Waye, J. P. Perentesis

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Hemoglobin E (HbE), α-thalassemia, and β-thalassemia are common among Southeast Asians and often occur in compound heterozygous states that complicate neonatal screening. We describe a kindred with α-thalassemia-1, HbE, and β0-thalassemia. The proband had HbE/β0-thalassemia, with severe anemia and failure to thrive. His father also had HbE/β0-thalassemia but had coinherited αthalassemia-1 and was free of symptoms.

Original languageEnglish (US)
Pages (from-to)863-865
Number of pages3
JournalJournal of Pediatrics
Volume132
Issue number5
DOIs
StatePublished - Jan 1 1998

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