Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Jack T. Stapleton; Henry H. Balfour

doi:10.1016/j.chom.2008.08.006

Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Jack T. Stapleton
, Henry H. Balfour

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

Original language	English (US)
Pages (from-to)	194-195
Number of pages	2
Journal	Cell Host and Microbe
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2008.08.006
State	Published - Sep 11 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Publisher link

10.1016/j.chom.2008.08.006

Find It

Find It at U of M Libraries

Cite this

@article{74b0857977b04dc38486a2212eececf6,

title = "Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV",

abstract = "The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.",

author = "Stapleton, \{Jack T.\} and Balfour, \{Henry H.\}",

year = "2008",

month = sep,

day = "11",

doi = "10.1016/j.chom.2008.08.006",

language = "English (US)",

volume = "4",

pages = "194--195",

journal = "Cell Host and Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Coinfection Alters the Playing Field

T2 - Herpesviruses Induce Acyclovir to Inhibit HIV

AU - Stapleton, Jack T.

AU - Balfour, Henry H.

PY - 2008/9/11

Y1 - 2008/9/11

N2 - The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

AB - The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

UR - https://www.scopus.com/pages/publications/51049119621

UR - https://www.scopus.com/pages/publications/51049119621#tab=citedBy

U2 - 10.1016/j.chom.2008.08.006

DO - 10.1016/j.chom.2008.08.006

M3 - Short survey

C2 - 18779044

AN - SCOPUS:51049119621

SN - 1931-3128

VL - 4

SP - 194

EP - 195

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this